Abstract
Long-lasting change of the synaptic efficacy of neurotransmission in the hippocampus is thought to be one of the physiological bases of memory. Acetylcholine, one of the neurotransmitters, is mainly released from the medial septum to the hippocampus. The activation of muscarinic acetylcholine receptors (mAChR) reportedly enhances hippocampal synaptic plasticity; however, the mechanism by which it does this remains unclear. We addressed the involvement of the inhibition of Kv7/M K+ channels, which are a target of mAChR modulation, during mAChR activation-induced enhancement of long-term potentiation (LTP) at rat hippocampal Schaffer collateral (SC)-CA1 synapses.
