On the stimulus effect of the autononic nervous system upon the mice's behavior (IV)

on the relation between Ad., Ach., and internal secretion

Abstract

Problem : As to effects of the sympathetic and parasympathetic nervous stimulus (ADRENALIN & ACETYLCHOLIN) on the behavior formation, the sympathetic nervous stimulus accelerates it at the first stage but represses it, after 15 or 20 min. while the para-sympathetic stimulus effects contrary. This proves CANNON'S theory of “HOMEOSTASIS” phenomenon (Fig. 1), and makes it possible to form susceptibility symptoms by successive stimuli of each of the sympathetic and para-sympathetic nerves. We introduced CANNON'S theory of “HOMEOSTASIS” and SELYE'S “STRESSOR” into the behavior formation and, at first, as the preliminary stage, we studied the relation between the autonomic nervous system and the internal secretion.
Procedure : apparatus, revolving wheel animals, mice (NA II)
General procedure ; After hypodermic injection of the internal secretion hormone, mice's momentus alteration of their free revolving for 30 min.was recorded.
Stimulants ; (1) PROGENIN which is regarded to accelerate the production of adrenalin by simulating mainly the sympathetic nerves, and (2) ESTORADIN which is regarded to stimulate the parasympathetic nerves to product acetylcholin.
quantity used is 0.1cc National Unit respectively.
Results : (1) Effect of the progenin on the behavior is accelerated at first, and repressed 18-24 min., and that of the estoradin is contrary (Fig. 2).
This is the same result as the effect of the autonomic nervous stimulus on the behavior.
(2) Through studying the effects of successive stimulation by the progenin or estoradin on the behavior, that is, the formation of susceptibility symptoms, it is also possible to form the susceptibility symptoms of the internal secreting function just as that of the autonomic nervous system. The effect of the internal secreting function stimulus on the behavior is delayed a little in time and space compared with that of the nervous system stimulus.
(3) As to behavior formation as bodily changes by the external stimulus, both the nervous system function and the internal secreting function have much to do with it.
Further investigations of the functional relations between the bodily changes and the behavior are required, in connection with CANNON and SELYE'S “Sympathetic Nervous System → Humoral regulation→Anterior pituitary→Adrenocortex System”.