Returning individual genomic results to prospective cohort study participants with hereditary breast and/or ovarian cancer syndrome

Abstract

Hereditary breast and ovarian cancer (HBOC) is an inherited breast and ovarian cancer susceptibility disorder caused by pathogenic germline variants in BRCA1 or BRCA2. To promote personalized medicine, the individual genomic results are returned to the Tohoku Medical Megabank cohort participants carrying the BRCA1/2 pathogenic variant.