NCTAM papers, National Congress of Theoretical and Applied Mechanics, Japan
The 64th Japan National Congress for Theoretical and Applied
Session ID : OS2-01-02
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OS2-1
Mathematical model of mechano-chemical coupling in tissue morphogenesis
Yasuhiro INOUETaiji ADACHI
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Abstract

Tissue morphogenesis can be controlled by the coupling between biochemical and mechanical signals to derive the functional three-dimensional (3D) shapes of organs. To acquire a better understanding of the mechano-chemical coupling, we construct a mathematical model based on the understanding of the physical picture of ligand–receptor kinetics at the 3D cell surface. Simulations demonstrated that the coupling between the gene expression and cell shape occurs spontaneously to regulate the spatiotemporal gene expression at the tissue scale, indicating that the cell shape is a key regulatory link between multi-physical events or multi-scale phenomena at the subcellular and tissue scales.

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© 2017 The Japan Society of Mechanical Engineers
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