Host: National Committee for IUTAM
Co-host: The Japan Society of Applied Physics, The Society of Chemical Engineers, Japan, Society of Automotive Engineers of Japan, The Japanese Geotechnical Society, Japan Society of Civil Engineers, The Japan Society for Industrial and Applied Mathematics, Japan Association for Wind Engineering, The Japan Society of Mechanical Engineers, The Meteorological Society of Japan, The Japan Society for Computational Engineering and Science, Japan Society for Computational Methods in Engineering, Architectural Institute of Japan, Atomic Energy Society of Japan, The Japan Society for Aeronautical and Space Sciences, The Japanese Society for Multiphase Flow, Japan Association for Earthquake Engineering, The Mathematical Society of Japan, The Japan Society of Naval Architects and Ocean Engineers, The Heat Transfer Society of Japan, The Physical Society of Japan, The Japan Society of Fluid Mechanics, The Japanese Society of Irrigation, Drainage and Rural Engineering
Tissue morphogenesis can be controlled by the coupling between biochemical and mechanical signals to derive the functional three-dimensional (3D) shapes of organs. To acquire a better understanding of the mechano-chemical coupling, we construct a mathematical model based on the understanding of the physical picture of ligand–receptor kinetics at the 3D cell surface. Simulations demonstrated that the coupling between the gene expression and cell shape occurs spontaneously to regulate the spatiotemporal gene expression at the tissue scale, indicating that the cell shape is a key regulatory link between multi-physical events or multi-scale phenomena at the subcellular and tissue scales.