Analytical and Histological Studies on the Changes of Composition and Structure of Dentin by Melatonin Medication

Abstract

The purpose of the present study is to examine the influence of melatonin on the structure and composition of tooth dentin through the analytical and histological studies. In this experiment, five, six, and seven-day old SD rats were used. The number and size of calcospherites in predentin increased in proportion to the concentration of melatonin administered. In the high concentration group, the strong expression of ALP was observed. In EPMA analysis, Ca and P content were increasing by the melatonin treated group. By laser Raman microprobe spectrometry, a peak of PO₄^3- is highly at a high concentration group. It is considered that melatonin participates in the formation of incremental lines and the calcification mechanism of dentin.