2023 Volume 21 Issue 1 Pages 43-50
Metal implants such as titanium alloy and stainless steel, or biodegradable polymeric implants such as polyglycolic acid and polylactic acid are commonly used for the born fracture treatment. However, removal surgery of metal implants after fracture healing are required that increase the burden on patients. On the other hand, polymeric implants do not require a removal surgery, but their strength are not enough.
To resolve such issues, we focused on magnesium is an essential element and good bioabsorbability in the human body. In particular, high-purity magnesium does not contain alloying elements which are a target for biological safety consideration. Moreover, in vitro test showed the biodegradation period can be adjusted approximately 8 to 12 weeks or longer, and the strength can be maintained by controlling the purity, crystal grain size, and crystal orientation. The safety of magnesium implants will be confirmed and established through biological safety tests and clinical trials.
