Journal of Oral Tissue Engineering
Online ISSN : 1880-0823
Print ISSN : 1348-9623
ORIGINAL ARTICLES
Healing Mechanism Surrounding Transplanted Bone Using Transgenic Mice Expressing Red Fluorescent Protein in Vivo
Manabu INOUEKeishi OTSUMasato OHTSUKAKyoko TAKAFUJIHidemitsu HARADAAkira ISHISAKIHisatomo KONDO
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2016 Volume 14 Issue 2 Pages 74-82

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Abstract

In recent years, Use of dental implants is becoming more widespread; however, not all patients can receive implant treatment without bone grafting. Bone grafting is frequently performed in implant treatments, and graft materials include autogenous bone, allografts, xenografts, and alloplasts. The healing mechanism of the autogenous bone graft is not well known; therefore, this study examines the healing mechanism surrounding grafted bone, at both cellular and molecular levels, employing tissue derived from transgenic mice expressing red fluorescent protein in vivo to monitor cellular kinetics in situ and to elucidate the healing mechanism. Results of our study suggested that mineralized tissue regeneration was induced by the transplanted bone representing autogenous bone graft but occurred from the margin of the existing bone.

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© 2016 by Japanese Association of Regenerative Dentistry
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