Journal of Oral Tissue Engineering
Online ISSN : 1880-0823
Print ISSN : 1348-9623
ISSN-L : 1348-9623
ORIGINAL ARTICLE
Histological and TEM Observation of Subcutaneous Tissues Exposed to Particulate Copper, Nickel and Titanium
Setsuo SAITOHKaori SASAKITakashi NEZUMasayuki TAIRAYu SHIMOYAMAMinoru SASAKIShigenobu KIMURAKiyoto ISHIZEKI
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2010 Volume 8 Issue 2 Pages 102-106

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Abstract

The in vivo reaction against metal particles is still not well understood. We implanted particulate copper (Cu), nickel (Ni) and titanium (Ti) in subcutaneous tissues of the back of mice for 1 week and evaluated metal-implant-induced tissue reactions. In histological observations, Cu and Ni induced strong and moderate inflammation, respectively, while Ti caused little inflammation. Transmission electron microscope (TEM) observations clarified that a major inflammatory and body-defense cell was neutrophil against Cu and Ni, while no inflammatory cells were found around Ti. We speculated that tissue reactions against Cu and Ni were caused by eluted Cu and Ni ions, respectively, in the nearby tissues.

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© 2010 by Japanese Association of Regenerative Dentistry
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