1992 Volume 4 Issue 1 Pages 63-69
To establish the optimal dose of FAR-therapy (radiotherapy with 5-FU and Vitamin A) relative to the local control rate and the normal tissue tolerance dose, 309 patients with laryngeal squamous cell carcinoma, who were treated initially by FAR-therapy at the Department of Radiology, Kyushu University, between 1973 and 1988, were analyzed in retrospect. The local control rate increased with increase in the radiation dose, and the radiation injury rate increased substantially. Radiation complication, such as long-standing edema or ulceration, was observed in 5% of the patients with glottic cancer and supraglottic cancer at doses of TDF 100 and TDF85, respectively. The local control rates for glottic cancer at TDF 100 were 96%, 87%, 63%, and 10% for T1, T2, T3 and T4, respectively. In supraglottic cancer at TDF 85, they were 93%, 85%, 75% and 47% for T1, T2, T3 and T4, respectively. TDF 100 is recommended as the optimal dose for glottic cancer and TDF 85 is recommended for supraglottic cancer.
