Abstract
From May 1977 to December 1992, 165 patients with non-small cell lung cancer were treated with radiotherapy in Yamagata University Hospital. Ninety four patients were treated with 50 Gy or more for the primary site and 40 Gy or more for the pulmonary hilus and mediastinum. In the 94 patients, we analyzed the results of radiotherapy. Response rate and tumor control rate were examined with respect to primary tumor. Response rate was 82.1% for patients who received total doses on the primary tumor ranging from 60 to 84 Gy (mean TDF 113), as compared with 60.0% for patients who received 50 to 57 Gy (mean TDF 87). Patients treated with 60 to 69 Gy (mean TDF 112) had significantly higher 5-year tumor control rate (87.2%) than the 0% for patients treated with 50 to 57 Gy (mean TDF 87). Survival rate classified by radiation doses were examined according Co total doses on the primary tumor.Patients who received 60 to 69 Gy (mean TDF 112) had significantly higher 5-year survival rate (5.8%) than the 0% for patients received 50 to 57 Gy (mean TDF 87). We concluded that 60 Gy or more (TDF≥99) was needed for tumor control. There was no significant difference in response rate and tumor control rate between radiation schedule (split and continuous course). In patients with stage III, patients whose performance status improved during radiation therapy had a significantly higher 5-year survival rate (3.8%) than the 0% for patients with stationary/progressive PS. We surmised that PS improved and longer survival was obtained following tumor regression due to radiation therapy. Patients with stage IIIA had significantly higher 5-year survival rate (5.8%) than that for patients with stage IV, without significant difference as compared with stage IIIB. According to histologic type and induction of chemotherapy, significant difference in survival rate was not seen.
