Derivatives of Reactive Oxygen Metabolites Correlates with High-Sensitivity C-Reactive Protein

Abstract

Aim: High-sensitivity C-reactive protein (hsCRP) is a predictor of cardiovascular events. Although oxidative stress may also be related to cardiovascular disease, there are few studies comparing the two. We therefore examined the association of hsCRP, serum lipids, and derivatives of reactive oxygen metabolites (D-ROMs) in coronary artery disease.
Methods: We measured the levels of serum lipids, hsCRP, plasma brain natriuretic peptides (BNP) and D-ROMs in 131 consecutive patients undergoing cardiac catheterization. We divided these subjects into three groups according to their levels of hsCRP.
Results: In group C (hsCRP>3.0 mg/L), mean levels of serum D-ROMs were significantly higher than in groups A (hsCRP<1.0 mg/L) and B (hsCRP 1.0 to 3.0 mg/L). Serum levels of D-ROMs and log (hsCRP) correlated in the total population (r=0.479, p<0.0001), and D-ROMs, HDL-C, LDL-C and log-transformed plasma BNP were independent predictors of hsCRP (p<0.0001).
Conclusion: We concluded that oxidative stress increases in patients at high risk for cardiovascular events based on their hsCRP.