Depleted Leukocyte Mitochondrial DNA Copy Number in Metabolic Syndrome

Ching-Hui Huang; Shih-Li Su; Ming-Chia Hsieh; Wen-Ling Cheng; Chia-Chu Chang; Hsi-Lin Wu; Chen-Ling Kuo; Ta-Tsung Lin; Chin-San Liu

doi:10.5551/jat.8698

Original Article

Depleted Leukocyte Mitochondrial DNA Copy Number in Metabolic Syndrome

Ching-Hui Huang, Shih-Li Su, Ming-Chia Hsieh, Wen-Ling Cheng, Chia-Chu Chang, Hsi-Lin Wu, Chen-Ling Kuo, Ta-Tsung Lin, Chin-San Liu

Author information

Ching-Hui Huang
Division of Cardiology, Department of Internal Medicine, Changhua Christian Hospital.
Vascular and Genomic Research Center, Changhua Christian Hospital.
Shih-Li Su
Vascular and Genomic Research Center, Changhua Christian Hospital.
Division of Endocrinology and Metabolism, Department of Internal Medicine, Changhua Christian Hospital.
Ming-Chia Hsieh
Vascular and Genomic Research Center, Changhua Christian Hospital.
Division of Endocrinology and Metabolism, Department of Internal Medicine, Changhua Christian Hospital.
Wen-Ling Cheng
Vascular and Genomic Research Center, Changhua Christian Hospital.
Chia-Chu Chang
Division of Nephrology, Department of Internal Medicine, Changhua Christian Hospital.
Hsi-Lin Wu
Department of Neurology, Changhua Christian Hospital.
Chen-Ling Kuo
Vascular and Genomic Research Center, Changhua Christian Hospital.
Ta-Tsung Lin
Vascular and Genomic Research Center, Changhua Christian Hospital.
Chin-San Liu
Vascular and Genomic Research Center, Changhua Christian Hospital.
Department of Neurology, Changhua Christian Hospital.
Graduate Institute of Integrated Medicine, China Medical University.

Keywords: Hypertension, Hypertriglyceridemia, Metabolic syndrome, Mitochondrial DNA

JOURNAL OPEN ACCESS

2011 Volume 18 Issue 10 Pages 867-873

DOI https://doi.org/10.5551/jat.8698

View "Advance Publication" version (August 16, 2011).

Details

Abstract

Aims: Metabolic syndrome (MetS) is characterized by a group of defects of metabolic origin which are possibly involved in mitochondrial DNA (mtDNA) alteration of mtDNA content [Lee et al. Exp Biol Med, 2007; 232(5):592-606]. The present study was undertaken to ascertain whether alteration of leukocyte mtDNA copy number is related to MetS.
Methods: Eighty non-MetS subjects and 50 subjects with MetS were recruited. The mtDNA copy number of leukocytes from each group of subjects was measured using quantitative polymerase chain reaction.
Results: The mtDNA copy number of leukocytes in subjects with MetS was significantly lower than that of non-MetS subjects. Depleted mtDNA copy number is correlated with lower plasma HDL, higher triglyceride, higher HOMA-IR and hypertension, and is even more sensitive to MetS criteria.
Conclusions: Depleted leukocyte mtDNA copy number is related to the severity of MetS. Alteration of mtDNA copy number in leukocytes is proposed as a MetS biomarker involved in the bioenergetic change of mitochondria.

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