Cardio-Ankle Vascular Index in Heterozygous Familial Hypercholesterolemia

Vladimir Soska; Petr Dobsak; Ladislav Dusek; Kohji Shirai; Jiri Jarkovsky; Marie Novakova; Petr Brhel; Jana Stastna; Lenka Fajkusova; Tomas Freiberger; Tomoyuki Yambe

doi:10.5551/jat.9639

Original Article

Cardio-Ankle Vascular Index in Heterozygous Familial Hypercholesterolemia

Vladimir Soska, Petr Dobsak, Ladislav Dusek, Kohji Shirai, Jiri Jarkovsky, Marie Novakova, Petr Brhel, Jana Stastna, Lenka Fajkusova, Tomas Freiberger, Tomoyuki Yambe

Author information

Vladimir Soska
2nd Clinic of Internal Medicine, Masaryk University of Brno.
Department of Biochemistry, Masaryk University of Brno.
Petr Dobsak
Department of Sports Medicine and Rehabilitation, St. Anne's Faculty Hospital and Masaryk University of Brno.
Ladislav Dusek
Institute of Biostatistics and Analyses, Faculty of Medicine and Faculty of Science, Masaryk University.
Kohji Shirai
Internal Medicine, Sakura Hospital, Medical Center, Toho University, Chiba, Japan
Jiri Jarkovsky
Institute of Biostatistics and Analyses, Faculty of Medicine and Faculty of Science, Masaryk University.
Marie Novakova
Department of Physiology, Faculty of Medicine, Masaryk University of Brno, Brno, Czech Republic
Petr Brhel
Department of Occupational Medicine, St. Anne's Faculty Hospital and Masaryk University of Brno.
Jana Stastna
Children's Department of Internal Medicine, Faculty of Medicine, Masaryk University Brno.
Lenka Fajkusova
Center of Molecular Biology and Gene Therapy, University Hospital Brno.
Tomas Freiberger
Molecular Genetics Laboratory, Centre for Cardiovascular Surgery and Transplantation.
Tomoyuki Yambe
Department of Medical Engineering and Cardiology, Institute of Development, Aging and Cancer, Tohoku University.

Keywords: Atherosclerosis, Cardio-ankle vascular index, Familial hypercholesterolemia, Statins,, Ezetimibe

JOURNAL OPEN ACCESS

2012 Volume 19 Issue 5 Pages 453-461

DOI https://doi.org/10.5551/jat.9639

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Abstract

Aim: The cardio-ankle vascular index (CAVI) is a new non-invasive marker of arterial stiffness and atherosclerosis. The purpose of this study was to compare CAVI in patients with heterozygous familial hypercholesterolemia (FH) and in healthy controls.
Methods: 82 FH subjects (27 males, 65 females), aged 53.7±13.6 years without clinical symptoms of cardiovascular diseases and 359 healthy controls (121 males, 238 females), aged 43.9±14.9 years, were examined. CAVI was measured using the system VaSera® 1500.
Results: CAVI in FH patients was significantly higher (8.0±1.4) than in healthy subjects (7.5±1.3) p = 0.002; however, age, sex and BMI adjusted CAVI did not differ significantly (p = 0.061) between the FH group (7.5, CI: 7.3; 7.7) and control group (7.7, CI: 7.6; 7.7).
Conclusion: The study showed no significant difference in CAVI between heterozygous FH and healthy controls.

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