Journal of Atherosclerosis and Thrombosis
Online ISSN : 1880-3873
Print ISSN : 1340-3478
ISSN-L : 1340-3478
Original Article
Levels of Circulating Microparticles in Patients with Chronic Cardiorenal Disease
Yung-Lung ChenChih-Hung ChenChristopher Glenn WallaceHui-Ting WangChih-Chao YangHon-Kan Yip
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2015 Volume 22 Issue 3 Pages 247-256


Aim: Cardiac and renal diseases are common disorders that frequently coexist. We tested the hypothesis that the levels of circulating endothelial-derived apoptotic microparticles (EDA-MPs; CD31CD42bANV) and platelet-derived apoptotic microparticles (PDA-MPs; CD31CD42bANV) are useful biomarkers for predicting the presence of cardiorenal disease (CRD).
Methods: A total of 68 patients with chronic kidney disease (CKD) and angina pectoris (CKD-AP) undergoing cardiac catheterization were prospectively enrolled into group 1, 10 patients with coronary artery disease (CAD) without CKD were enrolled into group 2 (CADCKD) and 10 patients without CAD and CKD were enrolled into group 3 (CADCKD).
Results: The serum creatinine levels were significantly higher, whereas the estimated glomerular filtration rates (eGFRs) were significantly lower, in group 1 than in the other two groups (all p<0.02). The circulating levels of EDA-MPs and PDA-MPs did not differ between the patients with and without CKD (all p>0.2). However, the circulating levels of EDA-MPs and PDA-MPs were significantly higher in group 2 than in groups 1 and 3 (all p<0.03). In addition, differences were noted in the circulating EDA-MP and PDA-MP levels between groups 1 and 3, although without statistical significance (all p>0.09). Meanwhile, among the CKD patients, the subgroup analysis showed that the levels of MPs were significantly higher in those with CAD than in those without (all p=0.001), while a multivariate analysis demonstrated that CAD was the only factor independently predictive of high levels of circulating EDA-MPs and PDA-MPs (p=0.033).
Conclusions: The link with increased circulating levels of MPs is more consistent in patients with CAD than in those with CKD.

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この記事はクリエイティブ・コモンズ [表示 - 非営利 - 継承 4.0 国際]ライセンスの下に提供されています。
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