Chlamydia pneumoniae Infection was Associated with Risk of Mortality from Coronary Heart Disease in Japanese Women but not Men: the JACC Study

Naomi Sakurai-Komada; Kazuko A. Koike; Yuuki Kaku; Masaki Hiraki; Renzhe Cui; Tomoko Sankai; Shogo Kikuchi; Chigusa Date; Akiko Tamakoshi; Hiroyasu Iso

doi:10.5551/jat.2725

This article has now been updated. Please use the final version.

Chlamydia pneumoniae Infection was Associated with Risk of Mortality from Coronary Heart Disease in Japanese Women but not Men: the JACC Study

Naomi Sakurai-Komada, Kazuko A. Koike, Yuuki Kaku, Masaki Hiraki, Renzhe Cui, Tomoko Sankai, Shogo Kikuchi, Chigusa Date, Akiko Tamakoshi, Hiroyasu Iso

Author information

Naomi Sakurai-Komada
Center for Medical Sciences, School of Health Sciences, Ibaraki Prefectural University of Health Sciences.
Kazuko A. Koike
Center for Medical Sciences, School of Health Sciences, Ibaraki Prefectural University of Health Sciences.
School of Health Sciences Uekusagakuen University.
Yuuki Kaku
Department of Public Health Medicine, Graduate School of Comprehensive Human Science, and Institute of Community Medicine, University of Tsukuba.
Masaki Hiraki
Center for Medical Sciences, School of Health Sciences, Ibaraki Prefectural University of Health Sciences.
Renzhe Cui
Public Health, Department of Social and Environmental Medicine, Osaka University Graduate School of Medicine.
Tomoko Sankai
Industrial Safety & Health Dept., Canon Inc. Tride Plant.
Shogo Kikuchi
Department of Public Health, Aichi Medical University, School of Medicine.
Chigusa Date
Department of Food Science and Nutrition, Faculty of Human Life and Environment, Nara Women's University.
Akiko Tamakoshi
Division of Clinical Trial, National Center for Geriatrics and Gerontology.
Hiroyasu Iso
Public Health, Department of Social and Environmental Medicine, Osaka University Graduate School of Medicine.

Keywords: Chlamydia pneumoniae, Coronary heart disease, JACC study, Risk factor

JOURNAL OPEN ACCESS Advance online publication

Article ID: 2725

DOI https://doi.org/10.5551/jat.2725

The final version of this article is now available: Vol. 17 (2010) , No. 5 p.510

Details

Abstract

Aim: To investigate the association between Chlamydia pneumoniae infection and mortality from coronary heart disease, a nested case-control study was conducted for 39,242 Japanese who participated in the JACC Study.
Methods: Immunoglobulin A and G titers of C. pneumoniae were measured in stored serum samples collected from 209 patients (113 men and 96 women) who subsequently died of coronary heart disease after 13-year follow-up; and 209 controls matched for gender, age (±5 years) and area of residence.
Results: After adjustment for high-sensitive CRP and other cardiovascular risk factors, the multivariate odds ratio (OR) of coronary heart disease for highest vs. lowest tertiles of IgA titers was 2.69 (95%CI, 1.00-7.20), p=0.049 for women and 0.58 (0.23-1.46), p=0.25 for men (p for interaction=0.03). A similar association was observed by high (++) vs. low (-/±) titers of IgA: multivariate OR was 4.09 (0.86-19.4), p=0.07 for women.
Conclusions: Since high IgA titers indicate persistent and repeated infection, such a state is associated with an increased risk of coronary heart disease mortality for women.

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