Abstract
The clinical effects of Urokinase (UK) were observed in 96 patients with peripheral arterial and venous occlusion comparing with those of heparin. UK was administered at a dose of 60, 000 I. U. once to several times daily for 7-8 days, total dosis being 932, 000 I. U. in an average. The results were as follows.
1) UK treatment was more effective than heparin treatment not only in clinical signs or symptoms, but also in angiographical findings.
2) In 12 cases FDP level was measured before and after UK administration. Three out of four cases with increased FDP level after UK treatment showed marked improvement angiographically, whereas, in eight cases with unchanged FDP level only one showed improvement.
3) Side effects were observed in two out of 66 cases (3.0%) treated with UK, while three out of 30 cases (10.0%) treated with heparin. There was no severe side effects in the groups of UK treatment. From our experiences, the dosis of UK we have used seems not to be enough for the treatment. The data suggest that UK treatment must be further monitored more carefully concerning dosage and time to obtain a good result and that one shot intrevenous injection of high dose UK following by intravenous drip infusion at initial stage of treatment should be considered to expect the accerelation of the fibrinolytic activity.
