Studies of Platelet Aggregation Inhibitor (Mono Dansyl Cadaverine)

Abstract

Mono dansyl cadaverine is known as the in-hibitor of fibrin cross linking reaction.
In 1971, it was found to be an efficient inhibitor of the second phase of both ADP and norepine-phrine-induced aggregation of human platelet.
We found, this substance also inhibits the first phase of ADP, norepinephlline, collagen, arachidonic acid and thrombin.
By in-vitro study, monodansyl cadaverine in-hibits insulin effect in the rat liver and antagonize for binding of the insuline on the human platelet.
By in-vitro study, monodansyl cadaverine in-hibited the effect of Angiotensin II, not increasing the blood pressure in rabbits.