Abstract
Fifty-four patients were treated with clinofibrate (600mg/day) for 16 weeks to observe changes in serum lipid levels and apo AI, AII. The serum concentration of total cholesterol, triglyceride and phospholipid were reduced significantly, while HDL-cholesterol was increased significantly, resulting in reduction of atherogenic index significantly.
In patients with serum cholesterol above 250mg/dl, triglyceride above 150mg/dl and phospholipid above 250mg/dl, their average serum concentration were significantly reduced after administration of clinofibrate. The average serum concentration of HDL-cholesterol, however, was increased significantly in patients with HDL-cholesterol under 40mg/dl.
Serum concentration of apo AI was increased significantly following medication, on the other hand, no change in serum concentration of apo AII was recognized.
The reduction of atherogenic index in IIb predominated that of IIa and IV types after administration of clinofibrate.
Side-effects caused by this drug were not found in any of the patients.
