Abstract
The effect of Clinofibrate on lipids in plasma and lipoprotein, plasma apoproteins and the proportion of apo C subspecies in VLDL was studied. Eleven hyperlipidemic patients, consisting of 5 type IIa, 3 type IIb and 3 type IV, were given 600 mg of Clinofibrate per day or placebo, each for 8 weeks by cross-over design.
Following change was obseved after the Clinofibrate treatment.
1. Mean plasma cholesterol, triglyceride decreased significantly.
2. VLDL-chol, VLDL-TG and LDL-TG decreased significantly and HDL2-chol tended to increase and HDL3-chol tended to decrease.
3. Plasma apo C-II decreased significantly.
4. The relative proportion of apo C-III0 in VLDL decreased and that of apo C-II in VLDL increased.
5. Atherogenic index decreased.
