Abstract
To clarify the possible mechanism of hyperlipidemia in uremia, we have determined serum lipid levels, serum apoprotein (apo) C-II and E levels and postheparin lipolytic activity which consists of lipoprotein lipase (LPL) and hepatic triglyceride lipase (H-TGL) activities in 15 patients on maintenance hemodialysis and in 15 sex, age or serum triglyceride (TG) levels-matched normal controls. In addition, the relationship among various parameters in each group was investigated.
There was a significant decrease in serum total cholesterol (TC) and high density lipoprotein cholesterol (HDL-C) levels and H-TGL activity in the patient group when compared to those of normal controls.
Both serum apo C-II and apo E levels did not show significant changes between two groups regardless of age or sex.
There was a significant positive relationship between serum apo C-II and apo E levels in two groups.
In both groups, serum apo C-II and apo E levels showed a significant positive correlation to serum TG and TC levels. The correlation of TG to the apoproteins was much higher than that of TC.
In the patient group, LPL activity showed a significant positive correlation to serum apo C-II and apo E levels but not in the control group. Moreover, the patient group had a significant negative relationship between H-TGL activity and serum apo E levels, while no significant changes were observed in the control group.
These findings suggest that serum apo C-II and apo E levels may play an important role in the regulation of LPL and H-TGL activities in patients on maintenance hemodialysis.
