Effects of Intravenous Alimentation on Familial Hypercholesterolemia

Abstract

Hypercholesterolemia is well known to be one of the most important promoting factors on atherosclerosis. Intravenous alimentation (IVA) was performed to 6 patients of familial hypercholesterolemia (FH). IVA solution consisted of 80% of the carories from glucose and 20% from amino acid hydrolysate. Total 1, 200 Kcal solution was infused daily to the patients for 4 weeks.
Plasma total cholesterol and LDL cholesterol decreased significantly (p<0.001, respectively). Plasma triglyceride tended to increase. HDL cholesterol (p<0.02), apo A-I (p<0.05), apo C-II (p<0.02) and apo E (p<0.05) reduced significantly, but apo A-II showed no change. The increase of the apo C-II/C-III₁ area ratio in VLDL was shown by isoelectric focusing.
Blood glucose, IRI and FFA showed no circadian variation. Blood glucose kept the normal fasting level and IRI kept the two-fold basal level but FFA kept the extremely low level.
In conclusion, it was suggested that lipid restriction and parenteral alimentation of nutrients caused the absolute reduction of LDL precursor such as chylomicron and VLDL, resulting in the decrease of total and LDL cholesterol.