Abstract
Plasma triglyceride, insulin, triglyceride secretion rate (TGSR) and postheparin plasma lipoprotein lipase (LPL) were determined in rats with ventromedial hypothalamic (VMH) lesions after 1 and 12weeks, respectively.
The results were as follows:
1) 12weeks after VMH operations, VMH lesioned rats showed significantly higher over-night-fasting plasma triglyceride concentrations than controls, wheares no difference was found between these two groups 1week after VMH operations.
2) VMH lesioned rats showed significantly higher TGSR, and blood insulin concentrations than controls both 1 and 12weeks after VMH operations. There was a positive correlation between serum insulin levels and TGSR in VMH lesioned rats.
3) VMH lesioned rats showed significantly higher LPL activity and serum insulin concentration than controls both 1 and 12weeks after VMH operations. There was a positive correlation between plasma insulin levels and LPL activity in VMH lesioned rats.
In these results, we presume that in rats with one week after VMH lesions the adipose tissue has enough capacity of depositing overproduced circulatory triglyceride, however in rats with 12weeks after VMH lesions, the adipose tissue has restricted capacity due to full deposition of the triglyceride, developing hypertriglyceridaemia.
