Abstract
Renal hypertensive rats were divided into two groups. Group 1 rats were fed cholesterol rich diet and group 2 rats fed same diet and were intramuscularly injected the elastase. The effect of elastase on the mesenteric arteries was examined pathologically.
Body weight and blood pressure did not show any differences between the two groups. Serum, β-lipoprotein of group 2 was lower than group 1.
Histologically many mesenteric arteries of group 2 rats showed healed stage of arterionecrosis. Lipid infiltration into the arterial wall was severe in the early stage, but the arteries showing large amount of fibrinoid deposition in the intima or thickened intima resulted from absorption of fibrinoid substance showed little lipid deposition.
Fibronectin deposited in the luminal side of intima showing large amount of fibrinoid deposition and thickened intima with abundant acid mucopolysaccharides.
Impairment of plasma infiltration into the injured wall was discussed.
