1985 Volume 13 Issue 4 Pages 767-774
Platelet aggregation, circulating platelet aggregates (ratio), red blood cell deformability, plasma prostanoid (6-keto-PG F1α, TX B2), glycosylated hemoglobin, plasma lipids, plasma apoprotein, plasma anti-thrombin III, plasma fibrinolytic activity and calf blood flow were measured in patients with atherosclerosis and non-atherosclerotic controls to clarify the regional differences in atherosclerosis.
The group I serving as the control consisted of 86 men of the average age 50.9 years, the group II consisted of 60 men of the average age 69.0 years and with ischemic heart disease, the group III consisted of 43 men of the average age 68.0 years and with cerebral infarction, the group IV consisted of 12 men of the average age 69.3 years and with atherosclerosis excluding cardiac and cerebral regions, and the group V consisted of 16 men ofthe average age 69.6 years and with more than two regions of atherosclerosis of cardiac, cerebral and the other.
In patients with atherosclerosis (group II, III, IV and V) platelet function was enhanced, plasma total cholesterol was increased, apoprotein A-II was decreased and calf blood flow was also decreased compared to group I. Platelet aggregation, red blood cell deformability, and plasma fibrinolytic activity were increased in group III, and calf blood flow, plasma apoprotein A-I and A-II, plasma 6-keto-PG F1α were decreased in group III compared to group II. In group IV arachidonic acid-induced platelet aggregation and plasma fibrinolytic activity were increased remarkably compared to any other group. In group V TX B2 was increased remarkably compared to any other group. By multiple regression analysis, in group II circulating platelet aggregates (ratio) showed a significant correlation with calf blood flow, and in group III ADP-induced platelet aggregation showed a significant correlation statistically.
