1985 Volume 13 Issue 4 Pages 895-900
Fatty acids of plasma lipids from subjects at 2 weeks or 2 years after myocardial infarction and from age-matched controls were analyzed. The proportion of oleate (18: 1) in plasma cholesterol ester (Cho E) was higher in the myocardial infarction patient and the 18:1/18:2 (linoleate) ratio of plasma Cho E was positively correlated with either free Cho level or with triacylglycerol level. The selectivity of plasma lecithin: Cho acyltransferase (LCAT) for the endogenous lecithin species was determined to be in the order of saturated>>monoene>diene>tetraene>>pentaene plus hexaene species, which was quite different from that reported earlier. The molecular species of plasma Cho E were found to be the complete reflection of molecular species of Cho E produced by the LCAT, suggesting that the contribution of acyl CoA: Cho acyltransferase (ACAT) to plasma Cho E formation was negligible under the conditions examined.
