Proline-rich Protein (PRP) Levels in Various Disease

Abstract

PRP is present in chylomicron and d>1.21 fraction of human plasma. PRP was separated from lipoprotein-depleted serum by absorption to Intralipid. Antiserum to PRP was raised by rabbit and the serum concentration was assayed by single immunodiffusion. PRP levels in acute hepatitis and hepatic cirrhosis were lower than controls. PRP levels in fatty liver and nephrotic syndrome were higher. Also PRP levels in ischemic heart disease, diabetes mellitus, cerebrovasculer disease and hyperlipidemia were higher. Furthermore, patients with inflammatory disease had higher PRP levels. These data suggested that liver may be involved in PRP synthesis and possible relation to atherosclerotic disease and inflammatory disease, indicated.