Abstract
In type V patient, premarin injection ((12mg/day)×4 days) caused an increase in VLDL-triglyceride and a decrease in LDL-cholesterol and HDL-cholesterol. Premarin inhibited lipoprotein lipase (LpL) activity in post heparin plasma and purified bovin milk LpL activity.
Premarin increased the bind of LpL to VLDL, but newly added VLDL-triglyceride was not hydrolyzed in the presence of premarin. These results suggested that premarin may directly inhibit the catabolic system of VLDL into LDL and the inhibition may be due to re-utilization failure of the LpL enzyme caused by premarin, which strengthened the binding of LpL uneffectively to the lipid surface.
