Serum HDL Subfraction and Apolipoprotein in the Subjects of Fatty Liver

Abstract

The changes of serum HDL subfraction and apolipoprotein were investigated in the subjects of fatty liver associated with abnormal liver function tests. Significant high levels of serum triglyceride, apolipoprotein C-II, and C-III were shown before treatment, whereas HDL-cholesterol and HDL₂/HDL₃ ratio were decreased. The calory restriction and administration of Elaszym (6 tab/day) have resulted in the amelioration of the parenchymal liver dysfunction, and concomitant recovery of serum lipid, lipoprotein, and apolipoprotein profile. These results suggested that the dyslipoproteinemia in fatty liver was similar to that observed in the original diseases such as obesity.