Abstract
This study was carried out to determine the changes in blood coagulation, fibrinolysis and platelet function in 81 patients with acute myocardial infarction from 1st to 30th day.
Levels of plasma fibrinogen markedly increased and reached peak levels on 7th day after myocardial infarction and remained elevated until 30 days. Changes in plasma levels of α1-antitrypsin and C1-inactivator were similar to the changes of plasma fibrinogen.
Platelet count decreased during the first 7 days and gradually returned to the normal levels. Levels of β-TG and platelet factor 4, platelet-specific proteins, increased and reached peak levels on 3rd day after myocardial infarction and remained elevated for at least 2 weeks.
Levels of plasma antithrombin III decreased from 1st to 5th day and returned to the normal levels by two weeks after myocardial infarction. There were no significant changes in plasma α2-macroglobulin.
In fibrinolytic systems, levels of plasma plasminogen showed slight decrease for 2 to 3 days, but antiplasmin activities and levels of plasma α2-plasmin inhibitor increased and reached peak levels on 5th day after myocardial infarction and remained elevated during two weeks.
In acute period of myocardial infarction, increased antifibrinolytic activity was found accompanied with activation of blood coagulation and platelet. These changes returned to the almost normal levels within a month after myocardial infarction.
