Abstract
Four pedigrees with hyperalphalipoproteinemia (HALP) have been found since 1982 in Iwate Prefecture and total 5 homozygotes and 16 heterozygotes were studied for their plasma lipoprotein and apoprotein constituents.
As in familial hypobetalipoproteinemia, all HALP subjects demonstrated the decreased level of plasma LDL-C, which seems to contribute primarily to the low incidence of atherosclerotic disorders in these pedigrees. Furthermore, in HALP heterozygotes, longevity might be accerelated by the moderate increase of plasma HDL concentration.
Gradient-gel electrophoretic study revealed massive apoprotein E-rich matured HDL accumulation in HALP, suggesting impaired transfer and redistribution of cholesteryl ester to other lipoproteins.
