Size of Lipoprotein Particles in Patients with Hyperlipidemia, Diabetes, or Coronary Heart Disease by High Performance Liquid Chromatography

Abstract

Recently, abnormality of lipoprotein is given attention as one of the risk factors for atherosclerosis. The size of lipoprotein particles obtained from patients with hyperlipidemia, diabetes, or coronary heart disease, was measured by high performance liquid chromatography.
In patients with hyperlipidemia, serum total triglyceride showed a reverse correlation with the size of low density lipoprotein (LDL) particles (r=0.5245): the size of LDL particles became smaller as triglyceride level became higher. In diabetic patients small-very low density lipoprotein (VLDL), which was between VLDL and LDL, was detected, and frequency of small-VLDL in patients with adequate control of blood glucose, lipids, and body weight was equal to that in patients with inadequate control. Small-VLDL was not found in diabetic patients who were treated with insulin. High density lipoprotein particles had an inclination to bigger size in patients with diabetes or coronary heart disease.