Abstract
There are several kinds of tests to investigate the abnormal plasma lipoprotein profiles. The aim of this study is to investigate whether OGTT is a useful test for abnormal lipoprotein catabolism.
Sixteen normal subjects and eleven patients with diabetes mellitus (DM) were examined. Blood sugar, immunoreactive insulin (IRI) and serum lipid levels—total cholesterol (TC), triglyceride (TG), HDL-cholesterol (HDL-C)—were measured at fasting and 30, 60, 120 minutes after 75g of oral glucose administration. VLDL-cholesterol (VLDL-C), LDL-cholesterol (LDL-C) were calculated based on Friedwald's formula.
Results obtained are as follows:
1. Serum TC was not changed after 75g of oral glucose administration.
2. Serum TG was significantly reduced 120 minutes after the oral glucose administration.
3. VLDL-C was also reduced significantly 120 minutes after the oral glucose administration. LDL-C and HDL-C were increased but not significantly.
4. There was no significant change in serum lipid levels between normal subjects and patients with DM during OGTT.
These results suggest that the acute effect of oral glucose administration on serum lipids is mainly caused by catabolism of VLDL.
