Effect of Melinamide on the Serum Apolipoprotein A-IV in the Hypercholesterolemic Subjects

Abstract

The effect of Melinamide on the serum lipid and apolipoprotein was studied in the subjects with hypercholesterolemia. The significant decrease of serum cholesterol and phospholipid, and concomitant increase of HDL₂/HDL₃ ratio (p<0.05) were observed after Melinamide administration (2, 250mg/day, 16 weeks). The tendency of decrease in the levels of apo A-IV and B was demonstrated especially in the cases whose cholesterol reduced during therapy. These results suggested the serum apo A-IV might reflect the decrease of the exogenous cholesterol after Melinamide therapy.