1987 Volume 15 Issue 3 Pages 655-660
Species difference of lipid metabolism to estrogen treatment was studied in rabbits, rats, and chickens. Estradiol was administered to animals via subcutaneous injection or oral feeding at the doses of 2.0 or 30mg per kg body weight 8 times for two weeks. Marked and moderate increase were observed in the levels of plasma triglycerides and cholesterol respectively in chickens. While estradiol treatment resulted in decrease of plasma triglycerides and cholesterol levels in both rabbits and rats.
The ultrastructure of hepatocytes displayed lipid vacuoles, well developed endoplasmic reticulum and Golgi apparatus indicating active lipid synthesis in the liver of chickens, but not in those of rabbits and rats.
