The Relationship between Ultrawatersoluble LDL (UWS-LDL) and Platelet Aggregability

Tsugumichi UEMURA; Takemichi KANAZAWA; Masahiro IZAWA; Hirohiko KANEKO; Kogo ONODERA; Hirobumi METOKI; Yoshito SHIMANAKA; Reiko KAWAHARA; Yasaburo OIKE

doi:10.5551/jat1973.15.3_767

Tsugumichi UEMURA, Takemichi KANAZAWA, Masahiro IZAWA, Hirohiko KANEKO, Kogo ONODERA, Hirobumi METOKI, Yoshito SHIMANAKA, Reiko KAWAHARA, Yasaburo OIKE

Author information

Tsugumichi UEMURA
The Second Department of Internal Medicine, Hirosaki University School of Medicine
Takemichi KANAZAWA
The Second Department of Internal Medicine, Hirosaki University School of Medicine
Masahiro IZAWA
The Second Department of Internal Medicine, Hirosaki University School of Medicine
Hirohiko KANEKO
The Second Department of Internal Medicine, Hirosaki University School of Medicine
Kogo ONODERA
The Second Department of Internal Medicine, Hirosaki University School of Medicine
Hirobumi METOKI
Reimeikyo Rehabilitation Hospital
Yoshito SHIMANAKA
Reimeikyo Rehabilitation Hospital
Reiko KAWAHARA
Reimeikyo Rehabilitation Hospital
Yasaburo OIKE
Reimeikyo Rehabilitation Hospital

Keywords: Native LDL, UWS-LDL, Platelet aggregability

JOURNAL FREE ACCESS

1987 Volume 15 Issue 3 Pages 767-772

DOI https://doi.org/10.5551/jat1973.15.3_767

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Abstract

The effects of native LDL and UWS-LDL on the platelet aggregation induced by ADP, collagen, and epinephrine were investigated.
1) Native LDL inhibited slightly the platelet aggregation induced by ADP or collagen, but slightly enhanced it induced by epinephrine.
2) UWS-LDL enhanced markedly the platelet aggregation in these three aggregants.
3) UWS-LDL dialyzed against flowing water for 120 hours enhanced the platelet aggregation more than that for 48 hours.
It was speculated that the interaction between platelet and UWS-LDL plays a very important role in formation and progression of arteriosclerotic lesion.

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