Serum Apolipoprotein A-IV Levels Increase in Diabetic Patients with Nephropathy
1987 Volume 15 Issue 5 Pages 1159-1162
Details
1987 Volume 15 Issue 5 Pages 1159-1162
The relationship of serum apolipoprotein A-IV (apo A-IV) levels and abnormalities in renal function tests in patients with diabetes mellitus was investigated. Serum levels of apo A-IV were measured by rocket immunoelectrophoresis. Serum levels of apo A-IV as well as total cholesterol (TC) and triglyceride (TG) in 36 diabetic patients were higher than those of 50 normolipidemic healthy controls. In diabetic patients, apo A-IV levels were significantly higher in those patients with abnormal BUN, Cr, CCr values or with proteinuria than those without signs of nephropathy. Correlation coefficients between apo A-IV and BUN, Cr and CCr were 0.53, 0.56 and-0.75, respectively. But the levels of apo A-IV were not related to the values of TC, TG and PSP-test.
The conclusions are as follow: 1) serum levels of apo A-IV are high in diabetic patients with nephropathy. 2) The apo A-IV levels are correlated with the severity of their renal disease.
