Abstract
It is our purpose to investigate serum lipids, especially serum apoproteins in order to clarify the precipitating factors in atherogenesis in healthy elderly.
In this investigation 38 healthy Male elderly subjects aged 64.8±5.4 years (M±SD) and 12 healthy male young subjects aged 23.1±3.3 years were used, who all showed normal blood pressure levels, normal findings in ECG and normal renal or hepatic function tests. Fasting blood sample was obtained by venipuncture for measuring serum lipids and so on.
There were found the significantly increased values of serum cholesterol (Chol), triglyceride (TG), (VLDL+LDL)-Chol and beta-lipoprotein in healthy male elderlys as compared to healthy male youngs. Moreover, apoprotein B, C-II, C-III and B/A-I ratio were higher significantly in healthy male elderlys than in healthy male youngs. Apoprotein B and B/A-I ratio were also higher significantly in 28 healthy male elderlys than in 12 healthy male youngs, who all showed less than 240mg/dl of serum cholesterol and less than 200mg/dl of serum triglyceride.
In the group of male 50 cases consisting of 38 healthy male elderlys and 12 healthy male youngs, there were found significant positive correlations between apoprotein A-I and HDL-Chol, between apoprotein B and Chol, TG or body mass index (BMI), between apoprotein C-II and C-III, between Chol and BMI, and between TG and apoprotein C-II or C-III. Even in the elderly group of 38 healthy male elderlys there were also observed significant positive correlations between apoprotein A-I and HDL-Chol, between apoprotein B and Chol, TG or BMI, between apoprotein C-II and C-III, and between TG and apoprotein C-II or C-III.
It was concluded that healthy male elderlys showed the relatively increased values of serum apoprotein B, C-II, C-III and B/A-I ratio in addition to the increments of serum cholesterol and triglyceride as compared to healthy male youngs.
