Significance of Midband as a Risk Factor for Coronary Stenosis in Familial Hypercholesterolemia

Abstract

We studied the relationship between coronary stenosis and midband, which was observed between pre- and β-lipoproteins, examined by 3% polyacrylamide gel electrophoresis in familial hypercholesterolemia (FH). Subjects were 95 patients with FH, in whom 28 patients were evaluated by coronary angiography. Stenosis score was expressed as the sum of stenosis points of each fifteen AHA segments of coronary artery. The stenosis score and the frequency of ischemic heart disease (IHD) in midband-positive group were higher than those in midband-negative group. There were no significant differences in the levels of serum total cholesterol, triglyceride, lipoproteinlipids, or apoproteins except apo E, between midband-positive group and midband-negative group. Only the level of apo E was higher in midband-positive group. The results suggest that the presence of midband is one of risk factors for coronary stenosis in familial hypercholesterolemia.