Abstract
The proliferation of bovine aortic SMC was increased by hyperlipidemic LDL (HL-LDL) (44μg/ml as cholesterol) obtained from the Dextran Sulfate Cellulose Column (KNA-01) after plasmapheresis. The effects of heparin (HP) and glycosaminoglycans (GAGs) on the proliferation of bovine aortic SMC by HL-LDL were studied. Heparin suppressed the proliferation of both SMC cultured in DME with 5% FCS and with 5% FCS containing HL-LDL in a dose response manner. Although the suppression of increased proliferation of SMC by GAGs (except HA) was less marked than that of heparin, the effects of GAGs were more susceptible to the cells proliferated by HL-LDL in contrast to the results obtained by heparin. It is suggested from these results that GAGs might suppress the specifically the proliferation of SMC by HL-LDL, and that sulfated GAGs could be used as antiatherogenetic agents.
