1988 Volume 16 Issue 1 Pages 105-109
CS-514, a new inhibitor of endogenous cholesterol biosynthesis, has been shown to reduce plasma cholesterol concentration in both healthy and hypercholesterolemic subjects. In this study we compared the effect of CS-514 and probucol on plasma lipids in hypercholesterolemic subjects. After treatment with probucol, HDL-cholesterol as well as total cholesterol tended to decrease. After a washout period probucol was replaced with comparable doses of CS-514. All the patients showed decreased plasma cholesterol levels after CS-514 treatment. HDL-cholesterol levels increased significantly after CS-514. Plasma triglyceride levels showed no significant change throughout the study period. Thus, the two drugs differed in their effects on HDL-cholesterol.
