Abstract
In order to evaluate the possible effects of nifedipine and trichlormethiazide on the lipid and lipoprotein metabolism, 16 patients with essential hypertension were studied before and after 16 weeks' treatment with 30mg nifedipine or 4mg trichlormethiazide daily. Eight patients were treated with nifedipine. There was no change in the concentration of serum total cholesterol, HDL-cholesterol, LDL-cholesterol and VLDL-cholesterol. The concentration of serum triglyceride decreased slightly, HDL2-cholesterol increased slightly, HDL3-cholesterol decreased slightly after the administration of nifedipine for 16 weeks. Eight patients were treated with trichlormethiazide. The concentration of serum total cholesterol and triglyceride increased slightly after 4 to 16 weeks. HDL-cholesterol decreased significantly after 16 weeks. HDL2-cholesterol decreased slightly. LDL-cholesterol and VLDL-cholesterol increased slightly. Total cholesterol/HDL-cholesterol increased significantly after 16 weeks. These results could possibly suggest favorable effects of nifedipine and infavorable effects of trichlormethiazide on the lipid and lipoprotein metabolism of hypertensive patients.
