Effect of Margarine Loading on HMG Co-A Reductase Activity in Freshly Isolated Periferal Blood Mononuclear Cells

Abstract

HMG Co-A reductase activity was measured in freshly isolated peripheral blood mononuclear cells from 8 normolipidemic healthy volunteers before and 4 hours after 50g margarine ingestion. These studies have demonstrated that LDL-cholesterol levels and HMG Co-A reductase activity before margarine loading were positively correlated (p<0.05). And a significant decrease (p<0.02) has been demonstrated in mononuclear cell HNG Co-A reductase activity in responders in which LDL-cholesterol levels decreased after margarine loading. In non-responders LDL-cholesterol levels and HMG Co-A reductase activity dose not change significantly. In responders LDL-triglyceride, LDL-phospholipid and LDL-Apo-B levels decreased as much as LDL-cholesterol.