Abstract
Hypo α-lipoproteinemia is often related to hypertriglyceridemia. Lipoprotein lipase (LPL), hepatic triglyceride lipase (HTGL) and cholesteryl ester transfer protein (CETP) may have a role in this state. We gave a oral fat load to hypertriglyceridemic subjects in order to investigate these relations.
There were no differences in either LPL and HTGL activities between the hypertriglyceridemia patients and normal controls. After fat load, serum triglyceride (TG) elevated and maintained the level for a longer period in the hypertriglyceridemic subjects than in the normolipidemic controls.
High density lipoprotein 3 (HDL3) cholesterol decreased in both groups. HDL3 cholesterol of the normolipidemic subjects recovered in 10 hours, while that of the hypertriglyceridemic subjects stayed at a low level until 12 hours after fat load. CETP activity did not change significantly. However, significant positive relationships were found between the Δ HDL3-C Area (Δ HDL3-C×hours) and TG Area (PlasmaTG×hours), and between the Δ HDL3-C Area (Δ HDL3-C×hours) and Δ VLDL-C Area (Δ VLDL-C×hours).
Based on these results, we conclude that hypo α-lipoproteinemia with hypertriglyceridemia may be related to increased transfer of cholesteryl ester (CE) from HDL to TG-rich lipoproteins, and that the transfer may be accelerated by an increased mass of TG-rich lipoproteins as an acceptor rather than the stimulation of CETP activity.
