Abstract
We evaluated an assay method for remnant-like lipoproteins (RLP) using an immunoaffinity gel mixture of apo B-100 and apo AI monoclonal antibodies. RLP was expressed in terms of a cholesterol value.
Ten items in the serum including serum cholesterol, triglycerides, apolipoproteins (AI, AII, B, CII, CIII, and E), RLP and Lp (a) were tested via statistical multivariate analysis. The statistical analysis showed that Lp (a) was independent of other serum lipids and apolipoproteins, and RLP was like as a character of remnant lipoproteins.
We observed the relationship within RLP or Lp (a) levels and the number of diseased vessels of stenosis in 176 coronary artery diseases (CAD) group. Lp (a) and RLP elevated in proportion to the number of diseased vessels of stenosis. The results indicated that a raised serum Lp (a) was a risk factor for CAD. However, the result on RLP was not significantly, it may note discrepancy because of smaller patient in frequency caused by increased RLP rather than increased Lp (a).
RLP levels were significantly high in the null-type apo (a) isoform. Although we detected Lp (a) in the RLP fraction, the Lp (a) was regarded as a free-type apo (a) with low-molecule isoproteins.
