Abstract
To investigate the relationship between abnormal glucose metabolism and LDL receptor activity (LDL-RA), we, studied LDL-RA in 20 Japanese-Americans who had no symptoms or history of familial hypercholesterolemia. LDL-RA was measured using lymphocyte PHA response according to the method reported by Lipsky and Cuthbert.
75g oral glucose tolerance test (OGTT) was also performed on all subjects. The OGTT results proved to be normal in 11 subjects, and showed impaired glucose tolerance (IGT) in five subjects and diabetes in two subjects. In two subjects, the OGTT had to be stopped because of vomiting.
We compared LDL-RA with several factors, and found that LDL-RA was significantly correlated with the LDL level and with the LDL cholesterol level (r=0.46, 0.44, respectively, p<0.05).
We also determined that LDL-RA was frequently low in subjects with abnormal OGTT results, and that the ∑SG level apparently influenced LDL-RA more than the ∑IRI level did.
These results suggest that LDL-RA is partly affected by disorders in glucose metabolism.
