The Effects of Clinofibrate on Quantitative and Qualitative Abnormalities of Plasma Lipoproteins

Abstract

Seven patients with hypertriglyceridemia were studied. Those patients consisted of 2 type IIb and 5 type IV hyperlipidemia. The patients were given 600mg/day or 1200mg/day of clinofibrate every day for 4-12 weeks. The lipoproteins were fractionated by ultracentrifugation by Hatch and Lees' method before and after clinofibrate treatment.
In each lipoprotein fraction, TG, Chol and ApoB were measured. Plasma triglyceride decreased by 37.3% and VLDL-TG by 39%. Total cholesterol decreased by 12.6% and VLDL-Chol by 52%. IDL-Chol decrased by 32.5%. VLDL-Apo B decreased significantly. The results indicate that Clinofibrate treatment reduced Chol, TG and Apo B content in VLDL, and that treatment decreased the number of VLDL particles.