Abstract
All participants in the medical examination system of Tokyo Women's Medical College, who received a medical check-up in 1987, were followed for 5 years, and the incidence of arteriosclerotic diseases and their risk factors were studied. Logistic regression analysis was used to determine the risk factors for arteriosclerotic diseases. The incidence of disases were studied at each level of risk factors proven to be related to these diseases by logistic regression analysis. Significance was analyzed by X2 test.
1) The incidence was calculated as 1.07 persons for myocardial infarction, 2.50 persons for effort angina, 1.36 persons for stroke, 0.79 persons for transient ischemic attacks and 0.14 persons for arteriosclerosis obliterans per 1, 000 persons per year.
2) The only risk factor for myocardial infarction was age, while those for effort angina were age, LDL, HDL and maximal blood pressure. The risk factors for stroke were age and blood pressure, those of transient ischemic attacks were age and LDL, and those of aortic aneurysm were age, LDL and maximal blood pressure. The incidence of these arteriosclerotic diseases increased at higher levels of LDL and blood pressure, and at lower levels of HDL.
3) Our new index, LDL/HDL×5, was a more sensitive predictor of arteriosclerotic diseases than LDL or HDL.
