Abstract
To clarify the clinical significance of lipoprotein lipase mass in preheparin serum (preheparin LPL mass), its relationships with serum lipoproteins in 305 persons taking healthy check, the values in diabetic patients (n=36) as insulin deficient state and the value changes during bezafibrate administration in hypertriglyceridemic patients (n=40).
Preheparin LPL mass was not necessarily correlated well with postheparin plasma LPL mass. Preheparin LPL mass was negatively correlated with serum triglyceride levels, and positively with HDL cholesterol levels, but, not with total cholesterol levels in persons taking health check.
Preheparin LPL mass was negatively correlated with HbAlc in diabetic mellitus patients.
Preheparin LPL mass increased by administration of bezafibrate in hypertriglyceridemic patients.
From these results, it is suggested that preheparin LPL mass might be reflecting the amount of functioning LPL in the body. Namely, preheparin LPL mass might be one of the indicator of the LPL production rate in the individuals.
