Abstract
Mural thrombosis and serum lipid levels have been known to play a part in the pathogenesis of atherosclerosis. The present study was under-taken to elucidate the relationship between serum lipid levels and blood coagulation in the nephrotic syndrome. In coagulation profiles, the partical thromboplastin times and the prothrom bin times were variable. The thrombin times were prolonged in general and proportional to the levels of total serum cholesterol; on the other hand, plasma fibrinogen contents, prothrombin and plasma factor V activities were generally increased. There were positive correlations between plasma factor V activities and the levels of total serum cholesterol, triglyceride and β-lipoprotein. Euglobulin clot lysis times as well as serial thrombin times showed a tendency to prolong, and thus the results were contradict each other in fibrinolysis. There were no relationships between serial thrombin times and the levels of serum lipids, but the administration of glucocorticoids. Fibrin degradation products in blood were almost within normal limits. There were marked increases of composed fatty acids of total serum lipids in nephrotic syndrome.
