Abstract
Total cholesterol levels in serum α-lipoproteins were determined in the supernatant after centrifuge of the mixture of serum and heparin solution containing CaCl2. On the other hand, α-lipoprotein concentration was determined by immunochemical method following Laurell's report. As the results, it was found that serum α-lipoprotein concentration didn't show significant difference between young and old healthy controls. However, significant decrease of α-lipoprotein concentration was noted in hyperlipidemic subjects of Type IIb and Type IV by WHO-classification compared with those in controls. It is suggested that decrease of serum α-lipoprotein may related to the disturbance of clearance mechanism of triglyceride in pre-β-lipoprotein, and the phenomenon may result to the increase of pre-β-lipoprotein in serum.
